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RAD140
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RAD140

Browse:113 Date:2019-03-22 Font Size:Big Medium Small
RAD140
RAD140 Basic Info.
Product name:RAD140
CAS Number: 118237-47-0
MW:393.826 
MF:C20H16ClN5O2 
Purity:99.5%(HPLC)
Apprarance:White crystalline powder.
Usage: Gain muscle and lean mass
Introducion
RAD 140 is also called Testolone. It is an increasingly popular new compound. The orally bioavailable as a non-steroidal, selective androgen receptor modulator (SARM) that binds to the androgen receptor and the androgen receptor. It is the main site of action of the hormonal testosterone can increase muscle mass and enhance testosterone without producing adverse side effects of anabolic steroids. Early research and user reviews were less side effects than using steroids, and they worked better, making it one of the most exciting and powerful SARMs to date. RAD140 is currently being studied for the treatment of muscle deterioration and breast cancer.
History
RAD140 is currently being developed by pharmaceutical company Radius. Its initial discovery was originally published in 2010, which means that research is limited. However, in the initial study, company reports and user reviews have been very promising for muscle fitness, without the side effects of anabolic steroids. Internal studies have found that rad140 is actually being developed for the treatment of breast cancer and muscular dystrophy in postmenopausal women. According to the website, their research new drug application was accepted by FDA. It is predicted that the first human clinical trial will begin in 2017.
Benifits
1.Helps increase muscle mass
The biggest benefit of the RAD140 is to increase lean tissue without increasing fat. The researchers found that in a preliminary study of monkeys, the scientists observed an average weight gain of exceed 10% in just 28 days without any traditional side effects associated with testosterone. This can be found in the future in the human body in many serious diseases of fat and muscle tissue weight loss resulting in muscle atrophy (muscle tissue loss), fatigue and weakness, RAD140 in bone and muscle can help reverse this problem and enhance muscle And weight. This can be accomplished by increasing the growth of bone and muscle cells.
2.RAD140 can increase speed, endurance and endurance during high intensity training
Every time you go to the gym, you want to work longer and harder and get better results. When supplementing RAD140, it is usually report about increased speed, stamina, and endurance during exercise. In addition, due to the ability to increase muscle tissue and reduce fat, high-intensity training and interval training can be optimized each time. Because of  its selectivity, RAD140 can be used to improve the weight of prostate cancer patients without stimulating prostate growth. Like other SARMs, Rad140 imitates the positive effects of testosterone on bodybuilders while limiting side effects. Although the benefits of RAD140 itself have not yet been confirmed, SARMs of this type can help bodybuilding by increasing their strength and strength. This is accomplished through an increase in muscle mass and a decrease in adipose tissue, which are reported to increase stamina and endurance during high intensity interval training.
3.RAD140 has stronger anabolic effect than testosterone
Androgens are steroid hormones (such as testosterone) that are present in both men and women. In addition to their major role in sexual development and function, androgens also affect bones, muscles, liver, and brain. Both males and females need androgen for health activities, but these hormones begin to decline when they gowth. This decline is related to muscle mass and loss of physical strength and usually leads to fractures and physical disability. Testosterone replacement therapy is a common method for the treatment of androgen deficiency related diseases. Although this treatment is effective, there are many adverse side effects, such as male prostate cancer and female infertility. Overactivation of androgen receptors in some organs may lead to harmful diseases. Similarly, activating these receptors in other organs is also detrimental, and RAD140 offers new ways to treat hormone-related diseases.
4.RAD140 can reduce the side effects of testosterone
When taken with anabolic steroids, researchers in monkeys found that RAD140 reduced the side effects of testosterone stimulation on monkey prostate and seminal vesicles. In addition, many users of anabolic steroids said that this class of drugs harms liver health. However, for monkeys in the 28-day trial, even if the body weight increased in a short period of time (which may lead to liver damage), the liver enzymes of these monkeys were raised 10 times higher than the fully effective dose. Therefore, RAD140 alleviates the side effects of testosterone, and RAD140 interacts with the hormone receptors of muscle and bone tissue in the same manner as high-dose testosterone, and all have no estrogenic side effects caused by anabolic steroids.
5.Testosterone seems to have no side effects on genital anabolic steroids
From the initial studies on mice have found that low doses of RAD140 are required to stimulate muscle growth without affecting the prostate. That means that RAD140 has the ability to selectively stimulate muscle and bone growth, while reducing the impact on sexual tissues such as the prostate or the clitoris. (So it is yes, this means that RAD140 is safe for women)
6.RAD140 helps increase fat and reduce loss weight
RAD140 reduces body fat by increasing muscle and skeletal cells indirectly, which are more expensive to maintain. By increasing muscle mass, you can increase your metabolism and lose weight. Because of the ability of the RAD 140 to increase stamina, endurance, and speed during interval training, the user also reported increased muscle growth and reduced fat storage.
7.RAD140 is being tested for breast cancer
RAD140 was discovered and is currently being used by pharmaceutical company Radius to treat androgen receptor (AR) and estrogen receptor positive (ER+) breast cancer in postmenopausal women. In vitro studies completed in 2017 showed that RAD140 inhibited the growth of AR/ER+ breast cancer cells. The results of these studies support the further study of RAD140 as a treatment for breast cancer, and proposed human clinical trials for the first time.
8.RAD140 is thought to have neuroprotective effects on brain health of neurodegenerative diseases
As male testosterone levels decrease, the risk of disease in androgen-responsive tissues (including the brain) increases and Alzheimer's disease, a neurodegenerative disease, develops.
Androgens usually reduce amyloid beta accumulation, increase brain cell growth and synaptic plasticity (which is important for learning and memory), and some of the effects are attributed to the conversion of these androgens into other steroid hormones such as estrogen. People have been using testosterone to treat AR disease but may increase the risk of prostate cancer. According to research, RAD140 can protect rat brain from beta amyloid damage. RAD140 may be as effective as testosterone in reducing cell death, and there is no adverse effect on prostate. This is because RAD140 does not have the same structure as typical androgens. It will not be converted to other hormones.
Attention
Although rad140 has so many benefits but because it can increase muscle mass and increase muscle strength, World Anti-Doping Agency may consider it a "prohibited substance" and test it when evaluating high-level athletes. Therefore, most of the purchasers are buying in the name of scientific research.
如何工作的
How to effect?
RAD140 is a non-steroidal selective androgen receptor modulator (SARM). It stimulates androgen receptors in bone and muscle with greater affinity than reproductive organs. RAD140 is selective because once RAD140 binds, different proteins interact with the androgen receptor in a manner. Different cells react to RAD140 binding by releasing different proteins. The protein can then initiate or inhibit the effect of RAD140 on androgen receptors. This results in only some androgen receptors being activated throughout the body, but not all. The structure of RAD140 is also unique and does not imitate other hormone steroid structures such as testosterone. It prevents RAD140 from transforming into other hormones that our body does not accept. RAD140 stimulates bones and muscles while inhibiting the prostate and seminal vesicles, which are responsible for sperm production. In addition, RAD140 does not increase liver enzymes and is considered to have low toxicity in rats. RAD140 also activates androgen receptors in damaged brain regions (such as the hippocampus) in rats. It activates specific biochemical pathways (MAPK pathways) that improve cell health and viability. And sometimes used as a PCT for steroid users to maintain muscle mass between cycles. RAD140 selectively activates androgen receptors in specific tissues, such as bone and muscle, but does not activate them in other tissues. The RAD140 has recently gained popularity among fitness enthusiasts. Selective activities in bone and muscle increase growth and build. It is therefore considered an anabolic compound, which means it increases the use of proteins and the formation of new molecules. Different from other hormone therapy. RAD140 selectively activates androgen receptors in specific tissues, such as bone and muscle, but does not activate them in other tissues. The RAD140 has recently gained popularity among fitness enthusiasts. Selective activities in bone and muscle increase growth and build. It is therefore considered an anabolic compound, which means it increases the use of proteins and the formation of new molecules. 
Dose
Studies on male primates have shown that 20-30 mg per day for 24-36 hours is optimal for maximal skeletal hypertrophy. The study's safe duration lasted up to 12 weeks, but development trials may show up to 24 weeks of tolerance. Notably, RAD140 systematically modulates the neuro-excitatory amino acid kainate, which activates glutamate receptors in the brain. The role of the amino acid kainate in neuronal cell death (especially the hippocampus) has been proven to be a major cause of Alzheimer's disease. RAD140 has achieved positive results in the prevention of kainic acid production. Medical research published by the Endocrine Society shows that RAD140 can improve brain health through neuroprotection in just 13 days. For women's safety, lower doses are recommended. It is recommended that women start at 5 mg per day and no more than 10 mg per day. Current research shows that it can tolerate up to 12 weeks of use.
Providing convincing data from the latest scientific research The RAD140 can achieve results in as little as 4 weeks, but it is recommended to have a longer period of up to 12 weeks for best results. Some users said that they show amazing results only after a 6-week period. Because it directly targets muscle and skeletal tissues, RAD140 does not have side effects caused by steroid use. The only problem with RAD140 is limited clinical human studies conducted in the scientific community.
Risk and side effect
RAD140 is a very new research substance, so there are no clinically reported side effects. The low side-effect profile is due to the selectivity of the action in the human body. This does not mean that RAD140 has no side effects or risks. The risk has not been determined. However, like other substances that affect testosterone levels, RAD140 may cause unwanted testosterone-related side effects. These may include:
Breast tenderness/male growth
Abnormal growth of female body hair
Change in sexual desire
Male pattern baldness/hair loss
Emotional fluctuations and anxiety/depression
Nausea and vomiting
Side effects methods:
Some of the regular side effects that users receive are headaches. Insomnia disappears with the correct dose.
Some side effects need to be cycled:
Body builders who use muscles like traditional steroid hormones or SARM to build male hormones need to recycle these substances. Usually, users will always add substances for 8 to 12 weeks. After one cycle is completed, the user needs to stop supplementing to restore the hormone to a natural level. This is called post-circulation therapy or PCT, and this is a necessary process to ensure supplemental safety with hormones. The length of the PCT may vary, but it is usually related to the length of the dosing period. For example, if a person is continuously replenished for 8 weeks, they should stop treatment for the same amount of time. However, some people may take a long time to recover from supplements.
Warnning
RAD140 is a promising candidate for treating many chronic diseases, but these benefits are yet to be explored in human studies. RAD140 has only been tested in rats and non-human primates. The results seen in animal studies do not always represent for human benefits.
Genes that may affect the effectiveness of RAD140
Patients with hormonal imbalance or androgen deficiency should use RAD140 with caution. Mutations in the androgen receptor gene AR may alter the body's response to RAD140. Depending on the nature of the mutation, RAD140 can increase or decrease activity in vivo. RAD140 may also have more side effects in patients with mutations in this gene.
Results
As a bodybuilding supplement, RAD140 assists in the development of lean muscle and loss of adipose tissue successfully. It can also increase exercise speed, endurance and endurance, thereby accelerating the loss of fat tissue and muscle growth. According to reports, compared with other SARMs, RAD140 shows its advantages in a short time. Most dosing cycles are 8 to 12 weeks, but RAD140 can benefit some people within 4 weeks. The time it takes to observe the result depends on the individual and their natural metabolism/adaptation level. Since RAD140 is selective for certain tissues, it has little effect on testosterone release. This is useful for women who want to increase muscle mass and increase muscle mass without becoming masculine.
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