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Levobupivacaine Hydrochloride Local Anesthesia Drugs Levobupivacaine HCL 27262

Browse£º694¡¡Date£º2019-05-08¡¡Font Size£ºBig¡¡Medium¡¡Small
Levobupivacaine Hydrochloride Local Anesthesia Drugs Levobupivacaine HCL 27262
 Basic information

Product name: Levobupivacaine hydrochloride,Levobupivacaine Hcl
Synonyms: (S)-(-)-Bupivacaine Hydrochloride
No.: 27262-48-2
Packing: 25kg/drum
M.F.: C18H29ClN2O
M.W.: 324.8887
Appearance: White crystalline powde


Usage:

Levobupivacaine HCl is intended for single use and does not contain preservatives; any solution remaining from an open container should be discarded. For specific techniques and procedures, refer to standard contemporary textbooks. Levobupivacaine Compatibility and Admixtures: Levobupivacaine may not be compatible with alkaline solutions having a pH greater than 8.5. Studies have shown that levobupivacaine is compatible with 0.9% Sodium Chloride Injection USP and with saline solutions containing morphine, fentanyl and clonidine. Compatibility studies with other parenteral products have not been studied. Dilution Stability: Levobupivacaine diluted to levobupivacaine 0.625 to 2.5 mg/mL in 0.9% sodium chloride injection is physically and chemically stable when stored in polyvinyl chloride (PVC) bags at ambient room temperature for up to 24 hours. Aseptic technique should be used to prepare the diluted products. Admixtures of levobupivacaine should be prepared for single patient use only and used within 24 hours of preparation. The unused portion of diluted levobupivacaine should be discarded after each use.


Dosage:

The doses in Table 3 are those considered to be necessary to produce a successful block and should be regarded as guidelines for use. Individual variations in onset and duration occur. Epidural doses of up to 375 mg have been administered incrementally to patients during a surgical procedure. The maximum dose in 24 hours for intraoperative block and postoperative pain management is 695 mg. The maximum dose administered as a postoperative epidural infusion over 24 hours is 570 mg. The maximum dose administered to patients as a single fractionated injection is 300 mg for brachial plexus block. For cesarean section, the maximum recommended dose is 150 mg. Children: The maximum recommended dose for infiltration analgesia (ilioinguinal-iliohypogastric block) is 1.25 mg/kg/side.


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